Anatomical Pathology

Fernando Constantino-Casas
MVZ PhD FRCPath MRCVS

Professional history
Fernando Constantino-Casas graduated with a Bachelor degree in Veterinary Medicine from the National Autonomus University of Mexico in 1985. He was awarded a PhD degree from the University of Cambridge in 1991. Fernando was head of the department of Pathology at the veterinary school in Mexico City from 2001 to 2006. He was then was appointed as Senior Lecturer in veterinary pathology, University of Cambridge in 2007 and as University Pathologist in March 2014. He has published 52 papers in peer review journals. He has supervised 14 undergraduate thesis, 8 Master thesis and 5 PhD thesis.

Special interests
Veterinary oncology.
Hepatitis and pancreatitis in dogs and cats.
Infectious diseases.
Syringomyelia in Cavalier King Charles Spaniels.
Pain assessment in sheep.
Please visit Fernando’s research profile for further information.

Recent publications
Roland R, Rad L, Wang W, Strong A, Ponstingl H, Bronner IF, Mayho M, Steiger K, Weber J, Hieber M, Veltkamp C, Eser S, Geumann U, Ollinger R, Zukowska M, Barenboim M, Maresch R, Caldinanos J, Friedrich M, Varela I, Constantino-Casas F, Sarver A, ten Hoeve J, Prosser H, et al. A conditional PiggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer. Nature Genetics, 47:1; 47-56. 2015.

Marcinowska A; Constantino-Casas F; Dobson JM. Histiocytic sarcoma in a flat coated retriever with central and peripheral nervous system sarcomatosis. Veterinary Record Case Reports 2014;2:1.

Rupp A, Ives E, Rudorf H, Constantino-Casas F. Sciatic T-cell neurolymphomatosis in a dog. Vet Rec Case Rep 2014;2;e000050.

Rad R, Strong A, Varela I, Kriegl L, Fraga MF, Calvanese V, Saur D, Price S, McDermott U, Eser S, Constantino-Casas F, Kirchner T, Yusa K, et al. A genetic progression model of BrafV600E-induced intestinal tumourigenesis reveals targets for therapeutic intervention. Cancer-Cell, 2013; 24, 1-15, July 8.

Furtado ARR, Constantino-Casas F. Histopathology inflammation scoring and classification in 34 dogs with inflammatory nasal disease. Veterinary Record, 2013, July 20.

Harris BJ, Constantino-Casas F, Archer J, Herrtage ME. Loeffler’s Endocarditis and Bicavity Eosinophilic Effusios in a Dog with Vesceral Mas Cell Tumour and Hypereosinophilia. Journal of Comparative Pathology, 2013;149(4), 429-33.

Abbondati E, Del-Pozo J, Hoather TM, Constantino-Casas F, Dobson JM. An Immunohistochemical Study of the Expression of the Hypoxia Markers Glut-1 and Ca-IX in Canine Sarcomas. Veterinary Pathology, 2013;50(6), 1063-1069.

Bexfield NH, Buxton RJ, Vicek TJ, Day MJ, Bailey SM, Haugland SP, Morrison LR, Else RW, Constantino-Casas F, Watson PJ. Breed, age and gender distribution of dogs with chronic hepatitis in the United Kingdom. The Veterinary Journal, 2012; 193;124-128.

Demetriou JL, Brearley MJ, Constantino-Casas F, Addington CE and Dobson J. Intentional marginal excision of canine limb soft tissue sarcomas followed by radiotherapy. Journal of Small Animal Practice, 2012; 53;174-181.

Vanhaesebrouck AE, Posch B, Baker S, Plessas IN, Palmer AC, Constantino-Casas F. Temporal lobe epilepsy in a cat with a pyriform lobe oligodendroglioma and hippocampal necrosis. Journal of Feline Medicine and Surgery 14, 2012; 932-937.

Hy HZ, Rusbridge C, Constantino-Casas F, Jeffery N. Distribution of substance P and calcitonin gene-related peptide in the spinal cord of Cavalier King Charles Spaniels affected by symptomatic syringomyelia. Research in Veterinary Science. Research in Veterinary Science, 2012; 93;318-320.

HZ Hu, Rusbridge C, Constantino-Casas F, Jeffery N. Histopathological Investigation of Syringomyelia in the Cavalier King Charles Spaniel. Journal of Comparative Pathology, 2012; 146;192-194.

Belshaw Z, Constantino-Casas F, Brearley MJ, Dunning MD, Holmes MA and Dobson JM. COX-2 expression and outcome in canine nasal carcinomas treated with hypofractionated radiotherapy. Veterinary and Comparative Oncology 2011; 9:141-148.

Constantino-Casas F, Mayhew D, Hoather TM and Dobson JM. The clinical Presentation and Histopathologic-Immunohistochemical Classification of Histiocytic Sarcomas in the Flat Coated Retriever. Veterinary Pathology 2011; 48:764-771.

Bexfield NH, Andres-Abdo C, Scase TJ, Constantino-Casas F, Watson PJ. Chronic hepatitis in the English Springer spaniel: clinical presentation, histological description and outcome. Veterinary Record, October 15, 2011; 169, 415.

Warland J, Dobson J, Constantino-Casas F. Hyperoestrogenism and mammary adenosis associated with a metastatic Sertoli cell tumour in a Pekignese. Veterinary Quarterly, December 2011, 31(4):211-214.

Peters SE, Paterson GK, Bandularatne ESD, Northen HC, Pleasance S, Willers C, Wang J, Foote AK, Constantino-Casas F, Scase TJ, Blacklaws BA, Bryant CE, Mastroeni P, Charles IG and Maskell DJ: Salmonella enterica serovar thyphimurium trxA mutants are protective against virulent challenge and induce less inflammation that the live-attenuated vaccine strain SL3261. Infection and Immunity 2010; 78:326-336.

Northen H, Paterson GK, Constantino-Casas F, Bryant CE, Clare S, Mastroeni P, Peters SE and Maskell DJ: Salmonella enterica serovar thyphimurium mutants completely lacking the F0F1 ATPase are novel live attenuated vaccine strains. Vaccine, 2010; 28:940-949.

Garcia-Marquez LJ, Vasquez-Garcia JL, Osorio-Sarabia D, Leon-Regagnon V, Garcia-Prieto L, Lamothe-Argumedo R and Constantino-Casas F. Lesiones pulmonares en tlacuaches (Didephis virginiana) infectados naturalmente por Paragonimus mexicanus en Colima, Mexico. Veterinaria Mexico 2010; 41:65-70.

Pastorello A, Constantino-Casas F, Archer J. Choroid Plexus carcinoma cells in the cerebrospinal fluid of a Staffordshire Bull Terrier. Veterinary Clinical Pathology, 2010;39:505-510.