Anatomical Pathology

Kate Hughes

Professional history
Kate undertook her veterinary training at the University of Liverpool, where she graduated with a BVSc awarded with distinction and a first class intercalated BSc (Hons). Following graduation, she worked as a clinical veterinarian prior to undertaking a residency in veterinary anatomic pathology at the University of Cambridge. At the end of her residency she passed the DipRCPath exams, and when she was eligible, she then passed the FRCPath. During her Wellcome Trust Research Training Fellowship (PhD studies) Kate was awarded the 2012 Royal College of Pathologists gold research medal for trainees.

Special interests
Companion animal neoplasia.
Mammary gland biology, including mammary tumours arising in companion animals.
Tumour associated macrophages.
Equine pathology.
Please visit Kate’s research profile for further information.

Current research
Kate studies tumour development and interactions between different cell types within the mammary gland. As a veterinary pathologist, and active diagnostician, she also has wider research interests in diagnostic veterinary pathology, including companion animal neoplasia and equine pathology.

Recent publications
Hughes K, Scase TJ, Foote, AK. Estrogen receptor and Signal Transducer and Activator of Transcription 3 expression in equine mammary tumors. Vet Path. In press; Epub ahead of print doi: 10.1177/0300985814559400.

Man SM, Ekpenyong A, Tourlomousis P, Achouri S, Cammarota E, Hughes K, Rizzo A, Ng G, Wright JA, Cicuta P, Guck JR, Bryant CE. Actin polymerization as a key innate immune effector mechanism to control Salmonella infection. Proc Natl Acad Sci USA. 2014; 111 (49): 17588-93.

Watson C, Hughes K. Breast cancer: the menacing face of Janus kinase. Cell Death Differ. 2014; 21 (2): 185-6.

Hughes K, Wickenden J, Allen J, Watson C. Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. J Pathol. 2012; 227 (1): 106–117.

Hughes K, Dobson J. Prognostic histopathological and molecular markers in feline mammary neoplasia. The Veterinary Journal. 2012; 194 (1):19-26.

Hughes K, Watson C. The spectrum of Stat functions in mammary gland development. JAK-STAT. 2012; 1 (3): 151–158.

Hughes K, Watson C. The role of Stat3 in mammary gland involution: Cell death regulator and modulator of inflammation. Horm Mol Biol Clin Invest. 2012; 10 (1): 211–215.

Scase T, Brandt S, Kainzbauer C, Sykora S, Bijmholt S, Hughes K, Sharpe S, Foote A. Equus caballus papillomavirus-2 (EcPV-2): an infectious cause for equine genital cancer? Equine Vet J. 2010; 42(8): 738-45.