Internal Medicine - Small Animal

Lucy Davison

Personal profile:
Lucy qualified from Cambridge as a veterinary surgeon in 1997, having intercalated in Pathology / Immunology in her third year. After several years in practice, Lucy passed the RVCS Certificate in Small Animal Medicine, then joined the Royal Veterinary College completing a PhD in clinical and immunological aspects of canine diabetes mellitus in 2004. This was followed by a residency in Small Animal Medicine in Cambridge, where Lucy passed her RCVS Diploma in Small Animal Medicine and DipECVIM-CA examinations in 2006, becoming a European Specialist in Small Animal Medicine (re-accredited 2011).

After a year at Cambridge Vet school as a Clinical Physician, Lucy undertook a 4-year Wellcome Trust Intermediate Clinical Fellowship at the JDRF / WT Diabetes and Inflammation Laboratory (Cambridge Institute for Medical Research) with Prof John Todd. Following this, she was awarded a 3-year Wellcome Trust Veterinary Postdoctoral Fellowship at Cambridge Vet School, in collaboration with Prof Chris O’Callaghan at the Wellcome Trust Centre for Human Genetics, University of Oxford.

Current research:
Gene expression
Type 1 diabetes

Recent publications
Lawrence J, Chang Y-M, Szladovits B, Davison LJ* and Garden OA* : Breed-specific hematological phenotypes in the dog: a natural resource for the genetic dissection of hematological parameters in a mammalian species PLoS ONE 2013 10.1371/journal.pone.0081288 (*equal contribution)

Butter F, Davison L, Viturawong T, Scheibe M, Vermeulen M, Todd, JA and Mann M. Proteome-wide analysis of disease-associated SNPs that show allele-specific transcription factor binding. PLoS Genet 2012 8(9): e1002982.

Davison LJ, Wallace C, Cooper JD, Cope NF, Wilson NK, Smyth DJ, Howson JMM, Saleh N, Al-Jeffery A, Angus KL, Stevens HE, Nutland S, Duley S, Coulson RMR, Walker NM, Burren OS, Rice CM, Cambien F, Zeller T, Munzel T, Lackner T, Blankenberg S, Gutenberg Heart Study, Cardiogenics, Fraser P, Gottgens B and Todd JA. Gene Expression and Long-range DNA looping Analyses Identify DEXI as an autoimmune disease candidate gene. Hum Mol Genet. 2012 Jan 15;21(2):322-33.

Lo B, Swafford AD, Shafer-Weaver KA, Jerome LF, Rakhlin L, Mathern DR, Callahan CA, Jiang P, Davison LJ, Stevens HE, Lucas CL, White J, von Borstel R, Todd JA, Lenardo MJ. Antibodies against insulin measured by electrochemiluminescence predict insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status. J Transl Med. 2011 Nov 28;9(1):203.

Swafford AS, Howson JMM, Davison LJ, Wallace C, Smyth DJ, Schuilenburg H, Maisuria-Armer M, Mistry T, Lenardo M, Todd JA. An allele of IKZF1 (IKAROS) conferring susceptibility to childhood acute lymphoblastic leukaemia protects against type 1 diabetes. Diabetes 2011 Mar;60(3):1041-4.

Davison, LJ, Herrtage, M.E. and Catchpole, B. Reactivity to recombinant canine proinsulin in the serum of dogs with naturally occurring diabetes mellitus. Res Vet Sci. 2011 Aug;91(1):58-63.